Tools for Practice


#115 Statins and cognitive impairment: Don’t forget the evidence?


CLINICAL QUESTION
Do statins have any effect on cognitive function or dementia?

BOTTOM LINE
Available evidence indicates that statins do not prevent, treat, or cause cognitive impairment or dementia. The FDA warning seems to be based primarily on case reports that may reflect idiosyncratic short-term “fuzzy” thinking. Decisions to prescribe statins should not be altered.  


CFPCLearn Logo

Reading Tools for Practice Article can earn you MainPro+ Credits

Join Now

Already a CFPCLearn Member? Log in



EVIDENCE
Five systematic reviews:1-5  
  • Overall [57 studies (19 Randomized Controlled Trials (RCT), 26 cohort, six case-control, six cross-sectional)]:1  
    • Incidence of dementia or cognitive impairment:  
      • One RCT (20,536 patients): no effect.  
      • Observational studies: generally statins reduce the incidence.  
        • Example: ten cohort studies (4,360,137 patients), Relative Risk 0.87 [0.82-0.92].  
        • These results are less reliable due to biases like lower risk people more likely to use statins. 
    • Performance on cognitive function testing:  
      • Eighteen RCTs (8,305 patients) including healthy, high cholesterol, or demented patients using a variety of cognitive tests: 
        • Of 155 statistical comparisons, 87.7% no effect, 4.5% statin better, 7.7% placebo better. 
        • Largest (5,804 patients), mean age 75, non-demented, followed three years: no difference in mini mental state examination (MMSE). 
    • Post-marketing surveillance on cognitive adverse events: 
      • No difference between statins and clopidogrel or losartan.   
  • Statins preventing dementia [two RCTs (26,340 patients)]:2 
    • No effect.  
    • Limits: cognitive function secondary outcome.  
  • Statins treating dementia [three RCTs (748 patients, mean age 79, with probable or possible Alzheimer’s disease, followed ≥6 months)]:3  
    • No effect. 
    • Trends generally favour statins preventing cognitive decline.  
      • Example: MMSE scores between statin and placebo (mean difference  -1.53, (-3.28 to 0.21). Not statistically significant. 
      • Limitations: highly inconsistent results. 
  • Two other systematic reviews found similar.4,5  
  Context:   
  • In 2012, the U.S. FDA warned that statins may produce cognitive impairment and memory loss/forgetfulness/confusion.6  
    • Appears based primarily on case reports.1  
    • May be better described as a “fuzzy” or unfocused thinking reaction.6 
      • It appears this is idiosyncratic, rare, and resolves when the medicine is stopped.6-8  
  • It has been proposed that lipophilic statins are more likely to cross blood-brain barrier and may have more central nervous system effects.6,7  
    • This is not based on reliable clinical evidence.  

Latest Tools for Practice
program image
Jennifer Potter MD CCFP

#348 How to Slow the Flow III: Tranexamic acid for heavy menstrual bleeding (Free)

In premenopausal heavy menstrual bleeding due to benign etiology, does tranexamic acid (TXA) improve patient outcomes?
Read 0.25 credits available
program image
Blair J. MacDonald PharmD

#347 Chlorthali-D’OH!: What is the best thiazide diuretic for hypertension?

Which thiazide diuretic is best at reducing cardiovascular events in hypertension?
Read 0.25 credits available
program image
Anthony Train MBChB MSc CCFP

#346 Stress Urinary Incontinence: Pelvic floor exercises or pessary? (Free)

How effective are pelvic floor exercises or pessaries for stress urinary incontinence?
Read 0.25 credits available
June 9, 2014

This content is certified for MainPro+ Credits, log in to access

Author(s):

  • G. Michael Allan MD CCFP
  • Grenvil Gracias MSc MD

1. Richardson K, Schoen M, French B, et al. Ann Intern Med. 2013; 159:688-97.

2. McGuinness B, Craig D, Bullock R, et al. Cochrane Database Syst Rev. 2009; (2):CD003160.

3. McGuinness B, Craig D, Bullock R, et al. Cochrane Database Syst Rev. 2010; (8):CD007514.

4. Swiger KJ, Manalac RJ, Blumenthal RS, et al. Mayo Clin Proc. 2013; 88(11):1213-21.

5. Macedo AF, Taylor FC, Casas JP, et al. BMC Med. 2014; 12:51.

6. U.S. Department of Health and Human Services: Food and Drug Administration (FDA). FDA Drug Safety Communication: Important safety label changes to cholesterol-lowering statin drugs; 2012. Available from: http://www.fda.gov/forconsumers/consumerupdates/ucm293330.htm (Accessed May 6, 2014)

7. Kelley BJ, Glasser S. CNS Drugs. 2014; 28(5):411-9.

8. Rojas-Fernandez CH, Cameron JC. Ann Pharmacother. 2012; 46(4):549-57.

Authors have no conflicts to disclose.