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#406 Scan, See, Decide: POCUS in the Evaluation of Dyspnea


CLINICAL QUESTION
QUESTION CLINIQUE
Is point-of-care ultrasonography (POCUS) helpful for the evaluation of undifferentiated dyspnea?


BOTTOM LINE
RÉSULTAT FINAL
For patients presenting to the emergency department (ED) with dyspnea, adding POCUS to conventional work-up improves the diagnostic accuracy of decompensated heart failure from ~87% to ~93%, and may improve diagnostic accuracy of other conditions. Length of ED stay is not different.



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EVIDENCE
DONNÉES PROBANTES
  • Results statistically significant unless indicated.
  • Two systematic reviews past 5 years, 5-7 randomized controlled trials (RCTs), 1483-1535 patients.1,2 Focus on three largest RCTs due to different protocols/outcomes. Diagnostic accuracy determined by masked chart audit.
  • 518 patients randomized after clinical evaluation to POCUS or chest X-ray/N-terminal pro-B-type natriuretic peptide.3 ED physicians, accredited training and >40 scans. Focus: B-line artifact (for decompensated heart failure diagnosis, present in ~43%).
    • Diagnostic accuracy: 95% (POCUS) versus 87%.
    • Sensitivity: 94% (POCUS) versus 85% (no statistics available).
    • Specificity: 96% (POCUS) versus 89% (no statistics).
    • Time to diagnosis: 5 minutes (POCUS) versus 105 minutes.
  • 442 patients randomized to conventional work-up alone (clinical evaluation, ECG, blood tests, most received CXR, with optional CT scans and formal echocardiography) or conventional workup plus POCUS.4 ED physicians, 4 hours of training and 10 practice scans. Focus: B-line artifact (decompensated heart failure, present in ~30%).
    • Diagnostic accuracy: 93% (POCUS) versus 87%.
    • Sensitivity: 88% (POCUS) versus 83% (no statistics).
    • Specificity: 95% (POCUS) versus 88% (no statistics).
    • Length of ED stay: Not different.
  • 315 patients randomized to conventional workup alone or conventional workup plus single expert physician-performed POCUS.5 Multiple views of cardiac/lung/deep veins for identifying any relevant diagnosis (most common: chronic obstructive pulmonary disease, pneumonia or heart failure).
    • Diagnostic accuracy: 88% (POCUS) versus 64%.
    • Appropriate treatment at 4 hours: 78% (POCUS) versus 57%.
  • Limitations: Various POCUS expertise and “diagnostic accuracy” definitions, CXR results in chart audit could bias final diagnosis determination.

CONTEXT
CONTEXTE
  • POCUS: Typically 8-view anterior and anterior/lateral lung, screening for increased tissue density (“B line artifact”), pleural effusion.3,4
  • POCUS: Positive likelihood ratio~20 (very good at ruling in heart failure), negative likelihood ratio ~0.1 (very good at ruling out heart failure).3,4
  • Training options examples: https://cpocus.ca; https://emergdoc.com.


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Author(s)
Auteur(s)
  • Émélie Braschi MD PhD CCFP
  • Jennifer Young MD CCFP-EM

1. Szabó GV, Szigetváry C, Szabó L, et al. Intern Emerg Med. 2023; 18:639–653.

2. Gartlehner G, Wagner G, Affengruber L, et al. Ann Intern Med. 2021 Jul; 174(7):967-976.

3. Pivetta E, Goffi A, Nazerian P, et al. Eur J Heart Fail. 2019; Jun; 21(6):754-766.

4. Baker K, Brierley S, Kinnear F, et al. Emerg Med Australas. 2020; Feb; 32(1):45-53.

5. Laursen CB, Sloth E, Lassen AT, et al. Lancet Respir Med. 2014 Aug; 2(8):638-46.

Authors do not have any conflicts of interest to declare.