#249 Helping physicians fatigued by TSH Screening and Subclinical Hypothyroidism

CLINICAL QUESTION

QUESTION CLINIQUE

Is there evidence for screening for thyroid function or treating subclinical hypothyroidism?  

BOTTOM LINE

RÉSULTAT FINAL

There is no randomized controlled trial (RCT) of screening for thyroid function [ordering thyroid stimulating hormone (TSH) in non-pregnant healthy people]. Despite approximately 20 RCTs, there are no patient-oriented benefits (like preventing cardiovascular disease or reduced fatigue or weight) in treating subclinical hypothyroidism. Guidelines recommend against both.

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EVIDENCE

DONNÉES PROBANTES

Screening for thyroid function: No RCTs or controlled observational studies assess screening for thyroid function or the use of TSH test for screening.^1,2 Treating subclinical hypothyroidism (TSH 4-10 but T3/T4 normal):

Clinical endpoints: Four systematic reviews (with 18-21 RCTs)^1-4 from the last 5 years report on 18-21 RCTs.^1-4 Treatment of subclinical hypothyroidism (levothyroxine typically) versus placebo had no effect on:
- Mortality or new cardiovascular disease.^2-4
- Quality of life, depressive symptoms, fatigue, or thyroid-related symptoms scores.^1-4
- Cognitive function.^1-4
- BMI/Weight.^1-4
- Newest RCT, 251 elderly patients (mean age 85), no benefit on any outcome (~1.5-year follow-up).⁵
Surrogate markers:
- Blood Pressure (BP): Three systematic reviews found no difference,1,2,4 while another found systolic BP reduced 2.5 mmHg (not diastolic).⁶
- Lipids: Of four systematic reviews, two found no effect and two found treatment reduced total cholesterol or LDL 0.1-0.6 mmol/L (no change in HDL or triglycerides).^7,8
- There is no evidence these small, inconsistent changes matter clinically.

Context:

Subclinical Hypothyroidism generally defined as TSH ~4-10mIU/L, with normal T3/T4 and no clear symptoms of hypothyroidism.
TSH may vary up to 50% between tests9 and daily fluctuations¹⁰ in individuals can be 26%.
Prevalence of subclinical hypothyroidism (in the developed world) is 4-10%, with 2-6% of these developing overt hypothyroidism. Subclinical hyperthyroidism prevalence is ~2% with 1-2% of these developing overt hyperthyroidism.^2,11
- 40% subclinical hypothyroidism revert to normal over ~2.5 years.¹²
- Symptoms are often poor predictors. Example: one study found ~18% of euthyroid, ~22% subclinical hypothyroid, ~26% overt hypothyroid patients reported ≥4 symptoms of hypothyroidism.¹³
Canadian Task Force on Preventive Health Care recommends against screening for thyroid function in asymptomatic non-pregnant patients or treating subclinical hypothyroidism.¹⁴