Tools for Practice


#279 What’s under the Mistletoe? Some fun holiday evidence from PEER


CLINICAL QUESTION
Are there any therapeutic benefits to kissing?


BOTTOM LINE
Kissing freely for 30 minutes while listening to soft music may improve surrogate markers of atopy (like wheal reactions on allergy test). Another small RCT found that advice to increase kissing improved relationship satisfaction and even slightly reduced (0.15mmol/L) total cholesterol. We did not identify studies of mistletoe. Further research is required.  



CFPCLearn Logo

Reading Tools for Practice Article can earn you MainPro+ Credits

Join Now

Already a CFPCLearn Member? Log in



EVIDENCE
Evidence:
  • Effect on atopy: 2 cross-over randomized controlled trials (RCTs)1,2of adults with allergic rhinitis or atopic dermatitis who “do not kiss habitually.” Randomized to compare hugging to kissing a lover or spouse freely for 30 minutes while listening to soft music [examples: When You Wish Upon a Star, Love is a Many Splendored Thing, Can You Feel the Love Tonight].
    • RCT, 60 individuals:1
      • Skin prick test wheal measurement before kissing was ~8mm and ~5.4mm immediately after kissing (statistically different).
      • Kissing caused a 30% relative reduction in neurotrophins.
    • RCT, 48 individuals:2
      • Kissing reduced immunoglobulin-E and 3 out of 5 cytokines.
    • Hugging: no effect on any outcome.
  • RCT exploring kissing and effect on relationship happiness and cholesterol: 52 (50% male, age 19-67) university staff and students randomized to advice to increase kissing with their partner compared to no advice, followed 6 weeks.3
    • Advice to kiss included: "Set aside a few minutes each day"; "Kiss each other more often"; Tell your spouse or romantic partner what you have been instructed to do"; "We hope you enjoy this".
    • Advice for kissing led to statistically significantly:
      • Less relationship conflict compared to control.
      • Improved relationship satisfaction (out of 7): 5.6 increased to 6.2, control unchanged.
      • Reduced stress (out of 7): 3.6 reduced to 2.9, control unchanged.
      • Reduced total cholesterol (4.73 to 4.58mmol/L), control unchanged.
  Context:
  • Observational data suggest attractive people (self-rated) report more kissing and greater kissing satisfaction while older people less satisfied with the amount of kissing.4Cause-and-effect have not been established.
  • Kissing should likely be limited to close household contacts during COVID-19 pandemic.
  • RCT5of the effect of maternal kissing of “boo-boo’s” was fictitious and not reported here. The fictitious nature was only noted after the article garnered attention.6
  • Effect of mistletoe on kissing has not been studied, but any associations may be confounded by eggnog and holiday cheer.


Latest Tools for Practice

#341 Forget about it? Statins and the risk of dementia (Free)

Do statins negatively affect cognition, memory, or dementia?
Read 0.25 credits available

#340 Crying babies: Can proton pump inhibitors help? (Free)

In infants (≤1year) with crying/irritability attributed to feeds, do proton pump inhibitors (PPIs) improve symptoms over placebo without additional harms?
Read 0.25 credits available

#339 Is acetaminophen under pressure?

Does regular use of acetaminophen increase blood pressure?
Read 0.25 credits available

This content is certified for MainPro+ Credits, log in to access


Author(s):

  • Adrienne J Lindblad BSP ACPR PharmD
  • Christina Korownyk MD CCFP
  • G. Michael Allan MD CCFP
  • James McCormack Pharm D
  • Jamie Falk PharmD
  • Jessica Kirkwood MD CCFP
  • Samantha Moe PharmD

1. Kimata H. Physiology Behav. 2003; 80:395-8.

2. Kimata H. J Psychosomatic Res. 2006; 60:545-47.

3. Floyd K, Boren JP, Hannawa AF, et al. Western J Commun. 2009; 73(2):113-33.

4. Watkins CD, Leongomez JD, Bovet J, et al. Scientific Rep. 2019; 9:6698.

5. The Study of Maternal and Child Kissing (SMACK) Working Group. J Eval Clin Pract. 2015; 21:1244-6.

6. Oransky I, Marcus A. Fake study on moms’ kisses risked sowing confusion just for a laugh. Available at: https://www.statnews.com/2016/01/13/journals-publish-fake-studies/ Accessed 17-NOV-2020.

Authors do not have any conflicts of interest to declare.