#228 The depressing evidence for antidepressants in the elderly
CLINICAL QUESTION
How effective are antidepressants for treating depression in the elderly?
BOTTOM LINE
The efficacy of antidepressants in the elderly is inconsistent and may decrease as patients age. From 80% to 40% of elderly patients will recover with antidepressants, with some studies showing no difference from placebo response rates. Harms of antidepressants are common, with ~20% stopping due to adverse effects.
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EVIDENCE
5 recent systematic reviews of randomized, placebo-controlled trials (RCTs) used different ages for inclusion:
- All antidepressants, mean age ~70, followed mostly 4 weeks (range 3-20), statistically different rates of “recovery” (achieving a set change in or reaching a predetermined depression score):1
- Tricyclic Antidepressants (TCAs) (10 RCTs): 75% versus 51% (placebo), Number Needed to Treat (NNT)=5.
- Selective Serotonin Reuptake Inhibitors (SSRIs) (2 RCTs): 83% versus 72% (placebo), NNT=10.
- SSRIs and newer antidepressants only: 10 RCTs, mean ages 68-80, followed 6-12 weeks, statistically different rates of:2
- Response (>50% improvement in symptoms): 44% versus 35% (placebo), results inconsistent.
- “Remission”: 33% versus 27% (placebo), results inconsistent.
- Any antidepressant: 15 RCTs, mean follow-up ~7 weeks:3
- Response (>50% improvement in symptoms): decreased with age:
- 54% for mean age 44, 42% for mean age 73.
- Placebo response rates similar regardless of age (~33-39%).
- Post-hoc analysis: no difference from placebo when limited to studies over age 65.
- Response (>50% improvement in symptoms): decreased with age:
- SSRIs only: 12 RCTs, mean ages 70-79, followed for mostly 8 weeks:4
- Response or remission: no difference compared to placebo.
- Limitations: Often based on secondary analysis.
- Likely no difference in efficacy between TCAs and SSRIs, but adverse-effect withdrawals higher with TCAs (24% versus 17%).5
- Elderly patients may respond to antidepressants slower than adults, possibly requiring 10-12 weeks before effects seen.2
- Chronic illness often co-exists with depression in elderly patients, along with frailty, possibly mitigating effects.6
- Cognitive Behavioural Therapy has been inconsistently shown to improve depression symptoms in the elderly.7,8
- In the elderly, antidepressants have been associated with a similar fall risk as benzodiazepines.9
- TFAntidepressants may not be effective in treating depression in dementia.10
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